Clinician-to-Clinician Update Clinician-to-Clinician Update

Stroke Care Specialty Updates

January 2017

January-2017-Stroke-Consult-Spec-Updates-Article-Image-EzzeddineMustapha 1972534667 MH Bio
— University of Minnesota Health neurologist Mustapha Ezzeddine, MD, serves as principal investigator of the CREST-2 trial.

Stroke Clinical Trials Announced

University of Minnesota Health announces 2 currently enrolling multicenter clinical trials on stroke interventions. Both are National Institute of Health StrokeNet trials. The University of Minnesota, Department of Neurology operates the only NIH StrokeNet regional coordinating center in the state.

CREST-2. The Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial (CREST-2) is for patients who have asymptomatic carotid stenosis, a condition that carries a high risk of major stroke. The multicenter, controlled trial will compare intensive medical treatment plus carotid revascularization via either stenting or endarterectomy to medical management alone. In many patients, carotid artery narrowing elicits mini-strokes, transient ischemic attacks, or symptoms consistent with strokes. Asymptomatic patients face the same rate of major stroke without the same warning signs.

DEFUSE 3. The phase III trial Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (Defuse 3) is designed for patients with acute ischemic anterior circulation strokes eligible for endovascular treatment between 6 and 16 hours after stroke onset. The study will evaluate the safety and efficacy of thrombectomy in selected patients over the longer period of time. The trial compares treatment with thrombectomy via approved devices and standard medical therapy to treatment with medical therapy alone. Clinical outcomes will be compared at 90 days following stroke.

For further information on the studies, contact Kathleen Miller at 612-624-8280,

In 2014, University of Minnesota Health joined the launch of StrokeNet, a network of 25 regional coordinating centers funded by the NIH. Each NIH StrokeNet hospital is tasked with leading large multicenter clinical trials in their regions that focus on interventions for stroke prevention, treatment, and rehabilitation. The network includes over 200 participating hospitals, a national coordinating center, and a national data center. More information on the initiative is available at

Related Articles

January 2017

Connecting Acute Stroke Patients to Advanced Care

As many as 1 in 20 deaths have been attributed to stroke. New endovascular therapies and systems of coordinated care are showing promise in improving these outcomes.

Continue reading

January 2017

Intra-arterial Thrombolysis Halts Brain Stem Stroke

Advanced imaging and specialized, team-based care enable a successful outcome for an elderly stroke patient whose condition was complicated by vascular disease.

Continue reading